What is the investigational TIL cell therapy process?

What is the investigational TIL cell therapy process?

In investigational TIL cell therapy, a small piece of an individual’s tumor is used to generate billions of energized TIL in a laboratory.¹

Tumor tissue removal

A small portion of the tumor is surgically collected and sent to a specialized laboratory

T-cell separation

The patient’s TIL are separated from other cells in the tumor

T-cell rejuvenation
and amplification

The TIL are then energized and multiplied into the billions

TIL infusion

The multiplied and reenergized TIL are administered back to the patient during a hospital stay

lnvestigational TIL cell therapy is a unique, individualized approach designed to recognize a multitude of immune markers and target cancer cells.^1,2

TIL=tumor infiltrating lymphocytes.

lnvestigational TIL cell therapy has 3 steps:

Step 1: Getting ready for the treatment

Patients receive chemotherapy to clear out immune cells so that the new treatment can work better.^1,2

Step 2: TIL infusion

Patients receive TIL cells, which can identify unique proteins displayed on the surface of cancer cells.²

Step 3: IL-2 Infusion

Patients receive a short course of high-dose IL-2 to help their TIL work better.²

After treatment completion, healthcare providers will monitor patients for any side effects.

IL-2=interleukin-2.

References:

1. Sarnaik AA, Hamid O, Khushalani NI, et al. Lifileucel, a tumor-infiltrating lymphocyte therapy, in metastatic melanoma. J Clin Oncol. 2021:39(24):2656-2666.
2. Wardell S, Lienlaf-Moreno M, Blaskovich M, et al. lovance Gen 2 TIL manufacturing process produces drug products that exhibit favorable quality attributes for adoptive cell transfer across 5 solid tumor indications. Poster P226 presented at: SITC Annual Meeting; November 6-10, 2019; National Harbor, MD.